![]() This difference in average CMT was found to be statistically significant ( P =. The average CMT for scans that successfully detected intraretinal/subretinal fluid using both acquisition patterns was 334 μm, compared to 296 μm in the 7 scans in which the 6-line radial failed to identify fluid. Owing to the observed significance, subgroup analysis was performed to determine whether CMT may influence the ability of the 6-line radial scan pattern to detect fluid in eyes with neovascular AMD. This difference in fluid detection between the 2 acquisition patterns for neovascular AMD was found to be statistically significant ( P =. The 6-line radial detected intraretinal/subretinal fluid in all but 7 scans from 5 patients (5.3% 95% CI 2.1%–10.5%), resulting in a sensitivity of 94.7% ( Figure 1 ). The 25-line raster detected the presence of intraretinal/subretinal fluid in all 133 scans. ![]() Neovascular Age-Related Macular Degenerationįor eyes with neovascular AMD, 133 SD OCT scans were interpreted (mean: 2.66 scans per eye). Fifty eyes were reviewed for each of the following disorders: neovascular AMD, DME, CRVO, BRVO, central serous chorioretinopathy, and vitreomacular traction and 65 eyes were reviewed with a diagnosis of full-thickness MH. McNemar testing was selected as it is most suitable for comparing nominal data that are also paired proportions.Ī total of 365 eyes that underwent Heidelberg SD OCT image acquisition using both 6-line radial and 25-line raster scan patterns were included. The McNemar test was used to determine if there was a statistically significant difference between 6-line radial and 25-line raster scan acquisition patterns in detecting the presence of intraretinal/subretinal fluid, vitreomacular traction, and full-thickness MH. Binomial confidence intervals (Clopper-Pearson method) were calculated for missed proportions of intraretinal/subretinal fluid, vitreomacular traction, and full-thickness MH. Categorical variables were reported as proportions. Statistical analysis was carried out using GraphPad software (GraphPad, La Jolla, California, USA). Additionally, scans with poor image resolution precluding adequate visualization of all retinal layers and the underlying RPE were excluded. Scans that did not detect macular pathology by either pattern type were excluded. Up to 5 examination dates were included where the aforementioned findings were detected by at least 1 of the 2 acquisition patterns. Using the OCT software caliper function, the aperture size was measured at the narrowest hole width in the mid-retina, as a line drawn roughly parallel to the RPE. OCT-based measurement of the minimum hole width, or aperture size, determined the hole size: small (250 μm and 400 μm). Next, full-thickness MH was defined as an anatomic defect in the fovea featuring interruption of all neural retinal layers from the internal limiting membrane to the retinal pigment epithelium (RPE). Conversely, for focal vitreomacular traction (70 scans) and full-thickness MH (82 scans), 25-line raster missed focal traction (1500 μm). 13), respectively, that was not detected by the 6-line radial. For CRVO (123 scans) and BRVO (126 scans), 25-line raster confirmed fluid on 2 ( P =. 32), respectively, that was not observed with the 6-line radial. For DME (140 scans) and central serous chorioretinopathy (91 scans), 25-line raster confirmed fluid in 4 scans ( P =. ![]() Sequential 6-line radial and 25-line raster scans were evaluated for intraretinal/subretinal fluid and, when applicable, vitreomacular traction and MH.įor neovascular AMD (133 scans), 7 25-line raster scans confirmed subretinal/intraretinal fluid not identified by the 6-line radial ( P =. Series of 365 eyes with neovascular age-related macular degeneration (AMD), diabetic macular edema (DME), central and branch retinal vein occlusion (CRVO/BRVO), central serous chorioretinopathy, vitreomacular traction, and full-thickness MH. To compare the 6-line radial vs the 25-line raster spectral-domain optical coherence tomography (SD OCT) acquisition patterns at detecting intraretinal fluid, subretinal fluid, vitreomacular traction, and full-thickness macular hole (MH).
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